Synergistic effects and mechanism of recombinant viral vector-mediated STAT1 overexpression and STAT3 silencing on glioma U251 apoptosis
The co-expression plasmid stat1/stat3-siRNA significantly induces apoptosis more effectively than individual stat1 and stat3-siRNA constructs. The potential mechanism involves the alternation of multiple nodes in the FOXO signaling pathway.
Authors
- Ping Huang (ORCID: https://orcid.org/0000-0003-1775-029X)
- Fang Wan
- Hong Li (ORCID: https://orcid.org/0000-0002-7715-6332)
- Guodong Zhang (ORCID: https://orcid.org/0000-0002-4847-0066)
- Xin-Long Hu
- Xiufeng Chen (ORCID: https://orcid.org/0000-0003-3394-8909)
- Haitao Ju
- Changwu Dou
- Chao Lin
Institutions
- Inner Mongolia Agricultural University (CN)
- Chifeng University (CN)
- Inner Mongolia University (CN)
- Aerospace Center Hospital (CN)
- Beijing Aerospace General Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1007/s11033-025-10585-1
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Inner Mongolia Medical University
- National Natural Science Foundation of China
- Inner Mongolia Agricultural University