Multi-omics analysis reveals Lactobacillus and Indolelactic acid involved in small intestinal adaptation of piglet with short bowel syndrome
Disrupted homeostasis of gut microbiota, metabolism, and transcriptome were reported in the SBS piglets. Multi-omics analysis demonstrated Lactobacillus and its metabolite ILA may be involved in small intestinal adaptation of SBS. These alterations may contribute to the proinflammatory state and the delay of intestinal adaptation in SBS, which in turn provide promising targets for therapies.
Authors
- Wei Cai (ORCID: https://orcid.org/0000-0001-9324-5987)
- Shicheng Peng
- Ying Lu (ORCID: https://orcid.org/0000-0001-7420-0206)
- Bo Wu (ORCID: https://orcid.org/0000-0001-5621-7653)
- Weipeng Wang (ORCID: https://orcid.org/0000-0003-3873-5881)
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12986-025-00938-9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China