Associations of leptin levels with psychopathology, BDNF and inflammatory cytokines in patients with chronic schizophrenia as well as gender differences
A significant link was identified between leptin levels and the presence of psychotic symptoms, BDNF, and inflammatory cytokines (especially IL-6 and IL-17 A) in individuals suffering from chronic schizophrenia, with notable variations observed between genders. Future research, including more longitudinal studies and animal models, is necessary to delve deeper into these associations and uncover their underlying mechanisms.
Authors
- Lewei Liu
- Pei Tang (ORCID: https://orcid.org/0000-0001-6717-8135)
- Huanzhong Liu (ORCID: https://orcid.org/0000-0003-3095-5249)
- Xianhu Yao
- Haojie Fan
- Wenzheng Li (ORCID: https://orcid.org/0000-0001-5127-2813)
- Lili Zhao (ORCID: https://orcid.org/0009-0005-3037-1704)
- Mingru Hao
Institutions
- Anhui Medical University (CN)
- The Fourth People's Hospital (CN)
- Chaohu Hospital of Anhui Medical University (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12888-025-06974-2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00