The Ancient Drug Salicylate Indirectly Targets Fructose‐1,6‐Bisphosphatase to Suppress Liver Glucose Production in Diet‐Induced Obese Mice
Collectively, our data highlight a novel mechanism of action for the effects of salicylate on glycaemia and weight gain, which depends on AMP-mediated allosteric inhibition of FBP1.
Authors
- Katarzyna M. Luda (ORCID: https://orcid.org/0000-0002-6647-3981)
- Kei Sakamoto (ORCID: https://orcid.org/0000-0001-8839-5980)
- Alison D. McNeilly (ORCID: https://orcid.org/0000-0003-4869-178X)
- Rory J. McCrimmon (ORCID: https://orcid.org/0000-0002-3957-1981)
- Graham Rena (ORCID: https://orcid.org/0000-0002-9121-1350)
- Douglas J. Lamont (ORCID: https://orcid.org/0000-0002-2262-5680)
- Raid B. Nisr
- Abdelmadjid Atrih
- Emmanuel Martínez Lara
Institutions
- University of Copenhagen (DK)
- University of Dundee (GB)
- Novo Nordisk Foundation (DK)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1111/apha.70058
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Diabetes UK
- Academy of Medical Sciences
- Novo Nordisk
- Novo Nordisk Fonden
- Medical Research Council