Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1α-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes
These findings indicate that Serpina3c is a significant regulator of adipocyte ER redox homeostasis, thus highlighting Serpina3c as a potential therapeutic target for obesity-related eWAT inflammation and heart damage.
Authors
- Peng Zheng (ORCID: https://orcid.org/0000-0003-4792-6364)
- Jiaqi Guo (ORCID: https://orcid.org/0000-0002-0254-0401)
- Yuyu Yao (ORCID: https://orcid.org/0000-0001-7841-288X)
- Mengchen Yang
- Shaofan Wang (ORCID: https://orcid.org/0000-0003-0085-3313)
- Genshan Ma (ORCID: https://orcid.org/0000-0003-4332-3013)
- Ya Wu
- Yu Jiang (ORCID: https://orcid.org/0009-0005-6998-759X)
Institutions
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-05-22
- DOI
- https://doi.org/10.4093/dmj.2024.0441
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33