NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging
Magnetic nanoparticles, especially iron oxide nanoparticles, have become versatile and widely used tools in nanomedicine due to their unique magnetic properties, biocompatibility, and tunable functionality. Liposomes have further enhanced the potential of iron oxide nanoparticles by serving as effective nanocarriers with advantages such as drug coencapsulation and enhanced molecular imaging properties. In this study, we present magnetoliposomes composed of ultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed as dual <i>T</i><sub>2</sub>-<i>T</i><sub>1</sub> magnetic resonance imaging (MRI) contrast agents for image-guided liposome degradation and infrared light-responsive nanocarriers in the second biological window for remote-controlled drug delivery. We demonstrated a dynamic shift from <i>T</i><sub>2</sub> to <i>T</i><sub>1</sub> MRI contrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells. Biodistribution studies using MRI and histological analysis confirmed their potential for <i>in vivo</i> applications. These results highlight the potential of LP-IONPs as image-guided and remote-controlled drug delivery systems.
Authors
- Pablo Martínez‐Vicente (ORCID: https://orcid.org/0000-0001-9277-1950)
- Laura Fernández‐Méndez (ORCID: https://orcid.org/0000-0002-8783-2330)
- Susana Carregal‐Romero (ORCID: https://orcid.org/0000-0003-1444-6268)
- Ainhize Urkola-Arsuaga
- Pedro Ramos‐Cabrer (ORCID: https://orcid.org/0000-0003-0368-7031)
- Yilian Fernández‐Afonso (ORCID: https://orcid.org/0000-0002-0970-1917)
- Jesús Ruı́z-Cabello (ORCID: https://orcid.org/0000-0001-8681-5056)
- Sandra Plaza‐García (ORCID: https://orcid.org/0000-0002-8694-009X)
- Lucía Gutiérrez (ORCID: https://orcid.org/0000-0003-2366-3598)
- Claudia Miranda-Pérez de Alejo
- Irati L. de la Pisa
Institutions
- Ikerbasque (ES)
- Universidad Complutense de Madrid (ES)
- University of the Basque Country (ES)
- Universidad de Zaragoza (ES)
- Instituto de Salud Carlos III (ES)
- CIC biomaGUNE (ES)
- Boeing (Spain) (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Ciencia de Materiales de Madrid (ES)
- Instituto de Nanociencia y Materiales de Aragón (ES)
- Digital Research Alliance of Canada
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1021/acsabm.5c00233
- Citations
- 2
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.19
Funders
- Fundación Ramón Areces
- Ministerio de Ciencia, Innovación y Universidades
- Eusko Jaurlaritza
- Ikerbasque, Basque Foundation for Science
- Gobierno de Aragón
- Fundación Contra la Hipertensión Pulmonar
- Instituto de Salud Carlos III
- European Regional Development Fund