Targeting COL5A1 enhances anoikis thus attenuating malignancy of glioblastoma via inhibiting the Wnt/β-catenin signaling pathway
These findings demonstrated the novel evidence that COL5A1 serves as an essential regulatory factor influencing both anoikis and malignancy of GBM cells by regulating Wnt/β-catenin signaling pathway, indicating that COL5A1 could be a novel prognosis-related biomarker and potential therapeutic target for GBM.
Authors
- Wei Wu (ORCID: https://orcid.org/0000-0003-4019-7920)
- Mingjing Zhou (ORCID: https://orcid.org/0009-0007-7816-7045)
- Pancheng Wu
- Yiyang Cao (ORCID: https://orcid.org/0009-0004-0061-6494)
- Beichen Zhang (ORCID: https://orcid.org/0000-0002-0927-9568)
- Jia Wang (ORCID: https://orcid.org/0009-0006-9377-8779)
- Haoyu Zhou (ORCID: https://orcid.org/0000-0002-6004-3761)
- Yichang Wang (ORCID: https://orcid.org/0000-0002-3128-7193)
- Maode Wang (ORCID: https://orcid.org/0000-0001-6255-682X)
- Xuyan Zhao (ORCID: https://orcid.org/0009-0004-4360-8574)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1007/s11060-025-05036-7
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Basic Research Program of Shaanxi Province