Region-based segmental swapping of homologous enzymes for higher cadaverine production
This study developed the improved strains for cadaverine production by creating the new enzyme, which is validated by enhanced amount of cadaverine. In addition, the segmental swapping guided by structure analysis was exhibited as the one of effective method in protein engineering strategies. These advancements offer a promising approach to optimizing cadaverine biosynthesis for industrial applications.
Authors
- Myung Hyun Noh (ORCID: https://orcid.org/0000-0001-9045-7968)
- Hyun Gyu Lim (ORCID: https://orcid.org/0000-0002-0469-2388)
- Seungjin Kim (ORCID: https://orcid.org/0000-0001-6113-9709)
- Jae‐Seong Yang (ORCID: https://orcid.org/0000-0001-9910-3170)
- Dae-yeol Ye
- Gyoo Yeol Jung (ORCID: https://orcid.org/0000-0002-9742-3207)
Institutions
- Pohang University of Science and Technology (KR)
- Inha University (KR)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12934-025-02739-4
- Citations
- 1
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Agencia Estatal de Investigación
- European Social Fund