ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing– a pilot study design
The trial is registered with ClinicalTrial.gov (NCT04543682), registered 02 Sep. 2020, https://clinicaltrials.gov/show/NCT04543682 and the German Clinical Trials Registry (DRKS00027081), registered 10 Nov. 2021 https://drks.de/search/de/trial/DRKS00027081 .
Authors
- Martin Textor (ORCID: https://orcid.org/0000-0001-8162-930X)
- Dominik Adl Amini (ORCID: https://orcid.org/0000-0002-8555-7304)
- Sven Geißler (ORCID: https://orcid.org/0000-0002-8750-6324)
- Melissa Paraskevaidis
- Hisham Elazaly
- Michael Dahne
- Matthias Pumberger (ORCID: https://orcid.org/0000-0002-0885-7370)
- Ioanna Maria Dimitriou (ORCID: https://orcid.org/0000-0002-2299-2042)
- Luis Lauterbach (ORCID: https://orcid.org/0000-0001-9461-385X)
- Sebastian Hardt (ORCID: https://orcid.org/0000-0001-8774-7585)
- Stefan Josef Schaller (ORCID: https://orcid.org/0000-0002-6683-9584)
- Melanie Ort
- Tobias Winkler (ORCID: https://orcid.org/0000-0003-0727-4680)
- Torsten Diekhoff (ORCID: https://orcid.org/0000-0003-3593-1449)
- Yannick Palmowski (ORCID: https://orcid.org/0000-0002-4555-036X)
- Sigmar Stricker (ORCID: https://orcid.org/0000-0002-7174-5363)
- Vera Jaecker (ORCID: https://orcid.org/0000-0001-8224-2414)
- Stephan Oehme (ORCID: https://orcid.org/0000-0001-5044-2657)
- Marcel Niemann (ORCID: https://orcid.org/0000-0001-7264-3089)
- Alexander Mielke (ORCID: https://orcid.org/0000-0002-4583-3888)
- Sebastian Braun (ORCID: https://orcid.org/0000-0003-4175-8718)
- Sascha Tafelski (ORCID: https://orcid.org/0000-0002-5623-8400)
- Lukas Schönnagel (ORCID: https://orcid.org/0000-0002-0743-8860)
- Vincent J. Leopold (ORCID: https://orcid.org/0000-0002-3476-4602)
- Tazio Maleitzke (ORCID: https://orcid.org/0000-0003-2924-7384)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Levent Akyüz (ORCID: https://orcid.org/0000-0003-1093-8505)
- Simon Reinke (ORCID: https://orcid.org/0000-0002-3451-9383)
- Paul Köhli (ORCID: https://orcid.org/0000-0001-7473-6553)
- Gerald Grütz (ORCID: https://orcid.org/0000-0003-4003-8639)
- Alp Paksoy (ORCID: https://orcid.org/0000-0002-1657-8961)
- Doruk Akgün (ORCID: https://orcid.org/0000-0002-5958-4472)
- Carsten Perka
- Alexander Hildebrandt (ORCID: https://orcid.org/0000-0003-3560-1642)
- Lukas Mödl (ORCID: https://orcid.org/0000-0001-5937-3563)
- Tobias Lindner (ORCID: https://orcid.org/0000-0003-4010-3445)
- Katharina Schmidt-Bleek
- Ulrich Stöckle (ORCID: https://orcid.org/0000-0002-6275-9747)
- Sven Maerdian
- Elisa Marie Planatscher
- Susana González-Khatib
- Maximilian Volcksdorff
Institutions
- University of Copenhagen (DK)
- Hvidovre Hospital (DK)
- Humboldt-Universität zu Berlin (DE)
- Zimmer Biomet (Germany) (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13018-025-05865-2
- Citations
- 2
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Deutsche Forschungsgemeinschaft
- Charité – Universitätsmedizin Berlin