HYPERTENSION IS ASSOCIATED WITH NEW MARKERS OF INSULIN RESISTANCE

Objective: Insulin resistance (IR) has an influence on blood pressure (BP). Data relating new IR markers to BP are scarce. Therefore, the aim of this study was to analyse the relationship between new IR markers and altered BP in an urban population. Design and method: A cross-sectional study was carried out with a sample of 1. 365 individuals to assess BP and IR markers: triglyceride glucose index (TyG), TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), metabolic score for IR (METS-IR) and cardiometabolic index (CMI). Participants were categorised into three groups based on BP levels: normotension (NT), pre-hypertension (PH) and hypertension (HT), according to the 2020 Brazilian Guidelines. For statistical analysis, the Kruskal-Wallis test was used, in addition to multinomial logistic regression (p<0.05). The ROC curve was used to explore the predictive capacity of BP parameters. Results: The average age of the individuals was 56.02 ± 14.56 years, and the prevalence of BP for NT, PH and HT was 30.33%, 7.18% and 62.49%, respectively. As the new IR indices increased, BP also increased (p<0.001), with the exception of the METS-RI and TG/HDL-C indices. In the multinomial logistic regression analysis, all the new IR markers were related to high BP levels, except for TG/HDL-C. TyG-BMI stood out as having a significant relationship with BP (OR=0.984; P=0.001). Analysis of the ROC curves (NT and PH) suggested that TyG-WC and TyG-WHtR outperformed other markers with higher odds ratios and area under the curve (AUC=0.667 in both cases) in all participants. The other markers had lower results for all three analyses. Analysing the ROC curve to identify NT and HT reveals that the TyG-WC and TyG-WHtR indices are also the most effective, with AUCs of 0.684 and 0.689, respectively. Conclusions: The new markers for IR were significantly associated with high BP, with the exception of TG/HDL-C and METS-IR. TyG-WC and TyG-WHtR can better predict PH and HT.