Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota
PMP markedly enhanced SCFAs and amino acid metabolism, as well as the proliferation of beneficial gut microbiota, thereby promoting intestinal health and barrier integrity, and thus relieving MCAO/R induced I/R injury both in brain and intestine. Our study substantiates the potential of PMP as a prebiotic health supplement in clinical settings for the prevention and treatment of IS.
Authors
- Hongyan Lin (ORCID: https://orcid.org/0000-0002-5743-0015)
- Lingyu Ruan
- Yuheng Tao
- Junsong Wang (ORCID: https://orcid.org/0000-0002-8935-4969)
- Qi Zheng (ORCID: https://orcid.org/0000-0002-2582-1222)
- Liqun Wang (ORCID: https://orcid.org/0000-0002-4429-3744)
- Wenhao Ge
- Zhennan Wang (ORCID: https://orcid.org/0000-0003-3877-8216)
- Qing Qing (ORCID: https://orcid.org/0000-0003-4715-0113)
- Mengyun Zheng
Institutions
- Lishui University (CN)
- Nanjing University of Science and Technology (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fphar.2025.1580055
- Citations
- 1
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Changzhou University
- Changzhou Science and Technology Bureau