PREDICTIVE VALUE OF SYSTEMIC INFLAMMATORY RESPONSE INDEX FOR CARDIAC MORTALITY AND CARDIOVASCULAR DISEASES IN GOUT PATIENTS: INSIGHTS FROM NHANES DATA

Objective: The systemic inflammatory response index (SIRI) is a predictor of inflammation and can serve as an indicator for gout patients. This study aimed to investigate the correlation between SIRI and cardiac mortality, as well as cardiovascular diseases (CVD) in gout patients. Design and method: A total of 1,417 gout patients from the NHANES (2007-2018) were included and divided into two groups (low level[R1 group] and high level[R2 group]) based on the optimal threshold value of the SIRI smooth curve. SIRI was calculated using the following formula: (neutrophil count × monocyte count)/lymphocyte count. Cox regression analysis was used to evaluate the relationship between SIRI and mortality, while the correlation between SIRI and CVD was explored by logistic regression. Subgroup analysis was used to explore the differing impacts of SIRI on gout patients with and without hypertension. Next, the receiver operating characteristic (ROC) curve was used to evaluate the predictive ability of SIRI in gout patients. Results: Over an average follow-up of 5.91 years, 321 participants died (86 from heart disease). Higher SIRI significantly increased the risk of cardiac and all-cause mortality (Table 1). SIRI was suggestively associated with a higher risk of CVD (Odds Ratio: 1.607, 95% confidence interval [CI]: 1.227-2.102, P < 0.001). In subgroup analysis, SIRI was significantly associated with CVD, cardiac, and all-cause mortality in gout patients with hypertension (P < 0.001) compared to those without (P > 0.05). Furthermore, SIRI accurately predicted CVD prevalence in gout patients (AUC: 0.7513, 95% CI: 0.7239-0.7787), and demonstrated strong predictive capabilities for cardiac and all-cause mortality (Figure 1).Conclusions: SIRI accurately predicts cardiac and all-cause mortality, as well as CVD, in gout patients. This association is more pronounced in those with hypertension.