ASSOCIATION OF ARTERIAL STIFFNESS PARAMETERS WITH CARDIAC REMODELING AND HEMODYNAMICS IN MIDLDE-AGED PATIENTS WITH HYPERTENSION STAGE 1

Objective: The main aim of this study was to determine correlation between parameters of arterial stiffness (Pulse wave velocity, augumentation index and amplification of pulse pressure) measured in the office (SphygmoCor) and during 24 hours (Mobil-O-Graph and Arteriograph) with hemodynamic and cardiac parameters in the group of young and middle-aged patients with stage 1 primary hypertension. Design and method: This study included 154 patients (average age 38.75±12.65 years, 69.5% men). The average age was 38.75±12.65 years. The majority of participants were overweight (48.7%) and had positive heredity on HT (89.6%) and CV diseases (65.4%). Pulse wave velocity (PWV), augumentation indeks (AiX) and amplification of pulse pressure (APP) were measured in the office and during 24 hours, and cardiac parameters were measured with approprirate echocardiographic and electrocardiogram parameters. Results: We found only higher values of office PWV values, and 24 hours and daily values using the Mobil-O-Graph to be associated with an increase in systemic vascular resistance (SVR) (p<0.05). Office arterial stiffness measurements were not inferior to 24-hour measurements in correlation between parameters of cardiac remodeling and hemodynamics. ROC analysis showed very low specificity and sensitivity for predicting left ventricular hypertrophy regardless of which method was used. Analyzing PWV, the lowest cut-off value was PWV measured using the Mobil-O- Graph and was 5.75. The highest cut-off value is the PWV measured during 24 hours using the Arteriograph with the corresponding sensitivity of 0.561 and slightly lower specificity of 0.467 and AUC of 0.507. Conclusions: We failed to find an association between arterial stiffness and hemodynamic and cardiac remodeling. In this cohort, the only important, although weak association was found for SVR. The other important finding is the lack of superiority of 24-hour arterial stiffness measurements over office measurement using SphygmoCor. Future multicentric studies with a larger number of subjects should be performed to prove or to reject findings.