PREVALENCE OF METABOLIC DISORDERS IN A SERIES OF 160 PATIENTS WITH PRIMARY ALDOSTERONISM

Objective: Metabolic syndrome (MetS) is a frequent clinical condition in hypertension patients and is more frequently reported in primary aldosteronism (PA). This study is aimed at investigating the prevalence of MetS and its components in the two major types of patients with adrenal venous sampling (AVS)-confirmed unilateral PA and bilateral PA.Design and method: This was a retrospective cross-section study. We analysed metabolic parameters from 160 PA patients subtyped by AVS, including 82 unilateral PA patients and 78 bilateral PA patients. Results: Patients with unilateral PA had higher aldosterone-renin ratio (ARR) and lower serum potassium than patients with bilateral PA. However, patients with bilateral PA had higher prevalence of MetS (79.8% vs 64.7%, P = .029), obesity (40.5% vs 24.7%, P = .029), dyslipidemia (41% vs 30.5%, P = .001) and obesità (34.6% vs 20.7%, P = .001) than those with unilateral PA. Meanwhile, bilateral PA had higher LDL-C (112 ± 0,46 vs 95,6 ± 0,50 mg/dl, P = .05), and tryglicerides (104 ± 0,48 vs 96 ± 0,50 mg/dl, P = .05). Conclusions: Patients with bilateral PA have a higher prevalence of MetS than those with unilateral PA, despite unilateral PA patients exhibiting higher concentrations of ARR and lower serum potassium, suggesting that unilateral PA and bilateral PA may have differing mechanisms of MetS.