Innate immune pathway activated mesenchymal stromal cells improve function and histologic outcomes in a rodent osteoarthritis model
These findings indicate therefore that innate immune activation of MSC prior to intra-articular delivery for treatment of OA can significantly improve functional gait activity and chondroprotective effects compared to non-activated MSC and suggest that this strategy could be evaluated clinically.
Authors
- Renata A. Impastato (ORCID: https://orcid.org/0009-0008-6602-102X)
- Kelly S. Santangelo (ORCID: https://orcid.org/0000-0002-2348-594X)
- Zoë J. Williams (ORCID: https://orcid.org/0000-0002-2852-2914)
- Isabella Sabino (ORCID: https://orcid.org/0000-0002-3513-6480)
- Katie J. Sikes (ORCID: https://orcid.org/0000-0002-3750-4777)
- Lynn Marie Pezzanite (ORCID: https://orcid.org/0000-0003-4990-5006)
- Lyndah Chow (ORCID: https://orcid.org/0000-0002-6413-9517)
- STEVEN W. DOW (ORCID: https://orcid.org/0000-0001-5488-9464)
- Cody Plaisance
Institutions
- Colorado State University (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fbioe.2025.1525969
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Institutes of Health