CLINICAL AND PROGNOSTIC SIGNIFICANCE OF NO LEVELS AND FMD TEST IN ENDOTHELIAL FUNCTION ASSESSMENT IN PREGNANT WOMEN WITH HYPERTENSION

Objective: to assess endothelial function in pregnant women with pre-existing hypertension using Flow-mediated vasodilatation test and level of nitric oxide (NO) concentration. Design and method: Study included 55 pregnant women of 2 groups. First group (n=34) of healthy pregnant women. Second group (n=24) of women with pre-existing hypertension. Endothelial function was also analyzed using flow-mediated dilation (FMD) test and level of nitric oxide (NO) concentration. NO level were assessed by P.P. Golikov method. Statistical processing was carried out using the Statistica 13.0 program. P < 0.05 was considered statistically significant. Results: there was no significant difference in age (27 in 1 group vs 29 in 2 group, P = 0.0658) and number of pregnancies (3.3 in 1 group vs 3.2 in 2 group, P = 0.7920). Mean level of blood pressure in group hypertension was: systolic blood pressure (SBP) of 153.83 mmHg. vs 102.72 mmHg in group 1 (P <0.0001), diastolic blood pressure (DBP) 96.16mmHg. vs 64.77 mmHg. in 1st group (P <0.0001). 23 women (95.8%) with hypertension were overweight, of which 15(62.5%) with obesity of I and II degree. In healthy group only 7 women (16%) were overweight, and no obese women. Mean value of FMD for 1 group was 6.2% vs 4.82 (P <0.0001), meanwhile NO was 8.8 mmol/l in group 1 vs NO 13.7 mmol/l (P <0.0001). Conclusions: Flow-mediated vasodilatation test measured by using an ultrasound system and determination of the blood serum NO level is associated with early diastolic dysfunction in overweight pregnant women with CHT.