Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant <i>Mycoplasma genitalium</i>
Minocycline with metronidazole cured 80% of macrolide-resistant infections in this cohort. Cure may be enhanced by the use of doxycycline before the combination regimen but larger studies are needed. Given limited options for treating resistant M. genitalium infections, the combined minocycline and metronidazole regimen may represent a promising option where no alternative drugs are available, or quinolones are contraindicated. Clinicians should be aware of and discuss side effects with patients.
Authors
- Laura Matthews
- Eric P. F. Chow (ORCID: https://orcid.org/0000-0003-1766-0657)
- Erica L. Plummer (ORCID: https://orcid.org/0000-0001-5710-2671)
- Christopher Kincaid Fairley (ORCID: https://orcid.org/0000-0001-9081-1664)
- Lenka A. Vodstrcil (ORCID: https://orcid.org/0000-0003-3679-9195)
- Ivette Aguirre
- Kay Htaik (ORCID: https://orcid.org/0000-0003-1754-4920)
- Catriona S. Bradshaw (ORCID: https://orcid.org/0000-0002-6643-5678)
Institutions
- The University of Melbourne (AU)
- Melbourne Sexual Health Centre (AU)
- Alfred Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1093/jac/dkaf142
- Citations
- 5
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- Australian Government
- Royal Australasian College of Physicians
- Medical Research Council
- National Health and Medical Research Council