Spectral and structural analysis of a new lactone metabolite isolated from a mangrove endophytic fungus

An unreported lactone, multiplolide I (<b>1</b>) was isolated from <i>Aspergillus</i> sp. GXNU-HLC1Y2-2. Through extensive spectral analyses, the structure of <b>1</b> was determined. The absolute configuration of multiplolide I was established <i>via</i> X-ray single-crystal diffraction analysis. Multiplolide I and four known compounds were evaluated for insecticidal activity against <i>Diaphorina citri</i> Kuwayama. The results revealed that <b>1</b> exhibited significant insecticidal activity against <i>D. citri</i> Kuwayama, with a lethality value of 93.96%.