Evaluation of Sensory and Motor Function in Spinal and Bulbar Muscular Atrophy Using Quiet Stance and Reactive Postural Control
This study confirms previously reported abnormalities of sensory postural control in SBMA and highlights patients' heavy reliance on visual inputs for postural control. Additionally, this study shows that automatic postural corrections are slower than normal in SBMA and provides a unique approach for measuring the combined sensory and motor components of the disease. Both the sensory and automatic balance abnormalities were found to be associated with plantarflexor weakness and may contribute to a higher risk of falls under challenging situations. Therefore, addressing this weakness may be an important step toward fall prevention in this population.
Authors
- Angela Kokkinis (ORCID: https://orcid.org/0009-0001-5683-1415)
- Cris Zampieri (ORCID: https://orcid.org/0000-0003-4632-7941)
- Joseph A. Shrader (ORCID: https://orcid.org/0000-0001-8174-0745)
- U. Jacobs
- Joshua G. Woolstenhulme (ORCID: https://orcid.org/0000-0002-6754-9036)
- Ashwini Sansare (ORCID: https://orcid.org/0000-0002-3218-1649)
- Kenneth H. Fischbeck (ORCID: https://orcid.org/0000-0002-8316-6895)
- Rafael Jiménez‐Silva
- Chris Grunseich
- Galen O. Joe
- Allison C. Niemic
Institutions
- National Institutes of Health (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Neurology International
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3390/neurolint17060079
- Citations
- 1
- Primary Topic
- Balance, Gait, and Falls Prevention
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- National Institutes of Health
- NIH Clinical Center