Transcription Factor‐Based Gene Therapy Enables Functional Repair of Rat Following Chronic Ischemic Stroke
Our study demonstrates that TF-mediated gene therapy has a broad therapeutic time window and can be applied multiple rounds to treat severe ischemic stroke, making it an attractive therapeutic intervention in the chronic phase after stroke, when current approaches are largely ineffective.
Authors
- Jiajun Zheng (ORCID: https://orcid.org/0000-0001-5005-9682)
- Menglei Li (ORCID: https://orcid.org/0000-0002-6362-9581)
- Hao Xu (ORCID: https://orcid.org/0000-0002-4447-7746)
- Kin Liao (ORCID: https://orcid.org/0000-0001-6352-2349)
- Wenliang Lei
- Wen Li (ORCID: https://orcid.org/0000-0002-4632-5754)
- Lu Wang (ORCID: https://orcid.org/0000-0003-2617-655X)
- Xu Wang (ORCID: https://orcid.org/0000-0002-8152-3342)
- Tao Wang (ORCID: https://orcid.org/0000-0001-5968-4935)
- Jinyu Wang (ORCID: https://orcid.org/0000-0001-5689-6174)
- Kun Zou (ORCID: https://orcid.org/0000-0001-5182-6855)
- Shanggong Liu
- Gong Chen
- Kai-Ying Wan
Institutions
- Jinan University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/cns.70448
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Jinan University
- National Natural Science Foundation of China-Guangdong Joint Fund