Diagnostic Performance of Clinical Metagenomic Next-Generation Sequencing for Suspected Central Nervous System Infections in a Municipal Hospital: A Retrospective Study in China
CSF mNGS showed superior diagnostic performance in CNSi and hence could serve as a complementary tool to CMT and conjunctively guide the precision therapy. Additionally, the values for CSF ADA, protein and pressure could assist in predicting mNGS positive result. With technical improvements for mNGS sample processing to increase throughput and reduce costs, clinicians may use mNGS more widely in municipal hospital laboratories.
Authors
- Jianting Zhao
- Wenlong He (ORCID: https://orcid.org/0000-0002-6684-8229)
- Xueyao Wang (ORCID: https://orcid.org/0009-0009-9386-0088)
- Tiantian Hu (ORCID: https://orcid.org/0000-0002-2695-4262)
- Huan Xu (ORCID: https://orcid.org/0000-0001-5861-0707)
- Min Dong (ORCID: https://orcid.org/0000-0001-6429-3891)
- Huimin Wang (ORCID: https://orcid.org/0000-0002-3955-3687)
- Miaomiao Li (ORCID: https://orcid.org/0000-0002-7328-0205)
- Zhenyong Che
Institutions
- Vision Medicals (China) (CN)
- Xinxiang Central Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/idr.s500279
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00