SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis
SRSF1 indicated poor prognosis and promoted the progression and cisplatin resistance of BCa cells through the HIF1A/BNIP3/mitophagy axis. It holds significant potential as a novel biomarker for the diagnosis and treatment of BCa, particularly in chemotherapy.
Authors
- Qiang Lü (ORCID: https://orcid.org/0000-0003-3589-2507)
- Juntao Zhuang
- Yuhan Chen (ORCID: https://orcid.org/0000-0003-3674-1516)
- Huanyou Sun
- Lingjing Jiang (ORCID: https://orcid.org/0000-0001-8706-2850)
- Kexin Bai
- Lingkai Cai (ORCID: https://orcid.org/0000-0002-1056-9116)
- Yiran Tao (ORCID: https://orcid.org/0000-0002-8894-5943)
- Haiwei Yang (ORCID: https://orcid.org/0000-0001-8984-5007)
- Xiao Yang (ORCID: https://orcid.org/0000-0002-5429-9162)
- Jiancheng Lv (ORCID: https://orcid.org/0000-0002-7698-8938)
- Hao Yu (ORCID: https://orcid.org/0000-0002-1185-332X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Institute of Metrology (CN)
- Jiangsu Province Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12967-025-06547-7
- Citations
- 6
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province