Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure
HF diagnostic model is developed based on 4 robust m5C RNA modification biomarkers (DNMT3B, NOP2, NSUN6 and DNMT1). Two distinct m5C RNA modification patterns in HF are identified, illustrating different IME characteristics. Our findings underline the significance of m5C regulators in HF, offering new perspectives on HF mechanisms and potential diagnostic and therapeutic strategies.
Authors
- Cao Zou (ORCID: https://orcid.org/0000-0002-4248-5822)
- Meili Liu (ORCID: https://orcid.org/0009-0005-8817-2775)
- Zirui Liu (ORCID: https://orcid.org/0000-0002-1939-9715)
- Weiqi Wang (ORCID: https://orcid.org/0000-0001-7104-3794)
- Rui Feng (ORCID: https://orcid.org/0000-0001-5283-3803)
- Ying Xu (ORCID: https://orcid.org/0000-0003-1705-1050)
- Jikai Wang (ORCID: https://orcid.org/0000-0002-5126-6840)
- Lu Yu (ORCID: https://orcid.org/0009-0007-9449-8274)
- Haocheng Wang (ORCID: https://orcid.org/0000-0001-8078-9475)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s41065-025-00454-z
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Jiangsu Commission of Health
- Soochow University
- Science and Technology Program of Suzhou