A model for cancer chemo-immunotherapy treatment schedules

This work constructs a generic model for chemo-immunotherapy of cancer in a healthy tissue. The main interests are the modeling and computer study of chemotherapy, immunotherapy and the advantages in their combined applications. It describes the dynamics of Healthy, Immune, and Cancer cells when chemotherapy and immunotherapy are applied, either separately or combined. The analysis of the model shows that its solutions exist, are bounded and nonnegative on each finite time interval, and thus are biologically feasible. The model simulations describe the development of the disease without intervention, when only chemotherapy or immunotherapy are administered periodically, when the two modalities are combined. In this manner, once validated, the model can be used to design treatment schedules for improved outcomes.