The REVIVE Project: From Survival to Holistic Recovery—A Prospective Multicentric Evaluation of Cognitive, Emotional, and Quality-of-Life Outcomes in Out-of-Hospital Cardiac Arrest Survivors

<b>Background/Objectives</b>: Most survivors of out-of-hospital cardiac arrest (OHCA) may suffer from cognitive, mental difficulties, and fatigue, which negatively impact their quality of life, despite a good physical recovery. However, no definitive data are available on this topic, so this study aims to assess the feasibility and acceptability of a centralized, sub-regional screening system for OHCA survivors in Italy and the prevalence of these disorders. <b>Methods</b>: OHCA survivors discharged with good neurological outcomes (Cerebral Performance Category (CPC) ≤ 2 and modified Ranking Scale (mRS) ≤ 3) from hospitals in the "Lombardia CARe" registry will be evaluated by a clinical psychologist using the Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), EQ-5D-5L for quality of life, and the Impact of Event Scale-Revised (IES-R) at pre-discharge or within 15 days and then at 1, 3, 6, and 12 months. Patients with clinical issues will be referred for psychological support or to a community rehabilitation program. Feasibility will be defined as a recruitment rate ≥ 80% and acceptability as a retention rate ≥ 50% over 12 months. <b>Results</b>: Based on historical data from the Lombardia CARe, an estimated 350 eligible survivors are expected, which will allow estimation of a prevalence ranging between 20% and 30% with 5% precision and 95% confidence. <b>Conclusions</b>: This study will be the first in Italy to evaluate the feasibility and acceptability of a centralized, sub-regional system for pre-/post-discharge evaluation of cognitive impairment, mental health, and quality of life in a large cohort of OHCA survivors, documenting the prevalence of these disorders.

Authors

Institutions

Publication Details

Journal
Journal of Clinical Medicine
Published
2025-05-22
DOI
https://doi.org/10.3390/jcm14113631
Citations
3
Primary Topic
Cardiac Arrest and Resuscitation
Type
article
Field-Weighted Citation Impact
6.76

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The REVIVE Project: From Survival to Holistic Recovery—A Prospective Multicentric Evaluation of Cognitive, Emotional, and Quality-of-Life Outcomes in Out-of-Hospital Cardiac Arrest Survivors

Diego Maffeo, Daniele Ghiraldin, Cristian Fava, Roberto Primi et al.
3 citations
Journal of Clinical Medicine
Cardiac Arrest and Resuscitation
6.76
article

The REVIVE Project: From Survival to Holistic Recovery—A Prospective Multicentric Evaluation of Cognitive, Emotional, and Quality-of-Life Outcomes in Out-of-Hospital Cardiac Arrest Survivors

Diego Maffeo, Daniele Ghiraldin, Cristian Fava, Roberto Primi, Filippo Dossi, Marco Mion, Luca Tarantino, A Mandrini, Sara Bendotti, Silvia Frattini, Federica Cipullo, Silvia Affinito, Davide Pegorin, Cecilia Fantoni, Simone Savastano, Angelica Praderio, Alessia Currao, Carlo Arnò, Giovanni Bertazzoli, Enrico Baldi, Paola Genoni, Gioele Papi, Leila Ulmanova, Cinzia Dossena, Massimo Torre
article en
3 citations

Abstract

<b>Background/Objectives</b>: Most survivors of out-of-hospital cardiac arrest (OHCA) may suffer from cognitive, mental difficulties, and fatigue, which negatively impact their quality of life, despite a good physical recovery. However, no definitive data are available on this topic, so this study aims to assess the feasibility and acceptability of a centralized, sub-regional screening system for OHCA survivors in Italy and the prevalence of these disorders. <b>Methods</b>: OHCA survivors discharged with good neurological outcomes (Cerebral Performance Category (CPC) ≤ 2 and modified Ranking Scale (mRS) ≤ 3) from hospitals in the "Lombardia CARe" registry will be evaluated by a clinical psychologist using the Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), EQ-5D-5L for quality of life, and the Impact of Event Scale-Revised (IES-R) at pre-discharge or within 15 days and then at 1, 3, 6, and 12 months. Patients with clinical issues will be referred for psychological support or to a community rehabilitation program. Feasibility will be defined as a recruitment rate ≥ 80% and acceptability as a retention rate ≥ 50% over 12 months. <b>Results</b>: Based on historical data from the Lombardia CARe, an estimated 350 eligible survivors are expected, which will allow estimation of a prevalence ranging between 20% and 30% with 5% precision and 95% confidence. <b>Conclusions</b>: This study will be the first in Italy to evaluate the feasibility and acceptability of a centralized, sub-regional system for pre-/post-discharge evaluation of cognitive impairment, mental health, and quality of life in a large cohort of OHCA survivors, documenting the prevalence of these disorders.

Journal of Clinical MedicineVol. 14(11)
University of Pavia (IT), Ospedale di Circolo e Fondazione Macchi (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Ospedale Maggiore (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Azienda Socio Sanitaria Territoriale Lariana (IT), Humanitas Mater Domini (IT), Azienda Ospedaliera Ospedale Maggiore (IT), Fondazione Poliambulanza Istituto Ospedaliero (IT), Ospedale Sant'Anna (IT), Policlinico San Matteo Fondazione (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Azienda Ospedaliera Ospedale Civile di Legnano (IT), Azienda Ospedaliera Carlo Poma (IT), Istituti Ospitalieri di Cremona (IT), Aziende Socio Sanitarie Territoriale Ovest Milanese, Aziende Socio Sanitarie Territoriale dei Sette Laghi, Azienda Socio Sanitaria Territoriale di Cremona, Anglia Ruskin University (GB)
Ministero della Salute
Openalex Percentile: Top 4%
Cardiac Arrest and Resuscitation
6.76
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.