APPLICATION OF CELL THERAPY IN THE COMPREHENSIVE TREATMENT OF PURULENTINFLAMMATORY DISEASES OF THE LOWER LIMBS IN THE CONTEXT OF CHRONIC VENOUS INSUFFICIENCY

Abstract. Currently, 1–3% of the population in industrially developed countries suffer from trophic ulcers of venous origin, with treatment costs accounting for approximately 1% of healthcare budgets in Western countries. Objective. To improve the outcomes of comprehensive treatment in patients with trophic ulcers of the lower limbs associated with chronic venous insufficiency through the application of cell therapy. Materials and Methods. A retrospective and prospective analysis of treatment outcomes was conducted in 110 patients aged 51–79 years with trophic ulcers of the lower limbs associated with chronic venous insufficiency. The patients were divided into two groups: 54 patients in the comparison group received conventional comprehensive treatment, including daily wound dressings with a 0.02% decamethoxin solution. In the main group of 56 patients, in addition to the aforementioned antiseptic wound treatment, autologous platelet-rich plasma (PRP) was injected into the wound area. Results. The obtained results demonstrated the convincing potential of PRP injections in influencing the wound healing process as part of the comprehensive treatment of patients with chronic nonhealing trophic ulcers. Conclusions. The application of PRP contributed to complete ulcer defect closure in 54 (94.7%) patients in the main group, compared to 44 (83.1%) in the comparison group. The wound healing dynamics in the comparison group were slower, with a healing rate of 0.2 cmІ/day, which was 2.1 times lower than in the main group (0.42 cmІ/day).