Analyzing the relationship of RNA and DNA methylation with gene expression
RNA methylation has a stronger effect on gene expression than does DNA methylation within gene bodies and promoters. DNA and RNA methylation in gene-bodies has a greater impact on gene expression than those in promoters. These findings deepen comprehension of the dynamics and complex relationships among the epigenome, epitranscriptome, and transcriptome, offering fresh insights for advancing epigenetics research.
Authors
- Darren E. Hagen (ORCID: https://orcid.org/0000-0001-8295-020X)
- Patricia Villamediana (ORCID: https://orcid.org/0009-0005-0726-6877)
- Morgan R Stegemiller (ORCID: https://orcid.org/0000-0001-9675-3047)
- Denise Konetchy (ORCID: https://orcid.org/0000-0002-9634-2421)
- Kimberly M Davenport (ORCID: https://orcid.org/0000-0003-2796-9252)
- Shuang Xie (ORCID: https://orcid.org/0000-0002-8821-2344)
- Jacob W Thorne (ORCID: https://orcid.org/0000-0003-3553-7628)
- Brenda M. Murdoch (ORCID: https://orcid.org/0000-0001-8675-3473)
- Stephanie McKay (ORCID: https://orcid.org/0000-0003-1434-3111)
- Gabrielle M. Becker (ORCID: https://orcid.org/0000-0002-1455-6443)
- Katie A Shira (ORCID: https://orcid.org/0000-0002-2289-440X)
- Sarem F. Khilji (ORCID: https://orcid.org/0000-0002-9139-9760)
Institutions
- Oklahoma State University (US)
- University of Idaho (US)
- Washington State University (US)
Publication Details
- Journal
- Genome biology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13059-025-03617-3
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- U.S. Department of Agriculture
- National Institute of Food and Agriculture