The role of the <i>ADRB2</i> Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank
In conclusion, the lung function-lowering allele of Thr164Ile is associated with traits and proteins indicative of a role in immune and lipid metabolism pathways, suggesting potential targets for therapeutic intervention.
Authors
- Richard Packer (ORCID: https://orcid.org/0000-0003-2459-1020)
- Nick Shrine (ORCID: https://orcid.org/0000-0003-3641-4371)
- Martin D. Tobin (ORCID: https://orcid.org/0000-0002-3596-7874)
- Kayesha Coley (ORCID: https://orcid.org/0000-0003-4951-6799)
- Robert J. Hall (ORCID: https://orcid.org/0000-0001-9114-7144)
- Louise V. Wain (ORCID: https://orcid.org/0000-0003-4951-1867)
- Ian P. Hall (ORCID: https://orcid.org/0000-0001-9933-3216)
- Katherine A. Fawcett (ORCID: https://orcid.org/0000-0002-6675-2112)
Institutions
- University of Nottingham (GB)
- University of Leicester (GB)
- Glenfield Hospital (GB)
- Nottingham Biomedical Research Centre (GB)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1183/23120541.00330-2025
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust