Defining occult disease in glioblastoma using spectroscopic MRI: implications for clinical target volume delineation
sMRI Cho/NAA > 2x delineates high-risk occult disease in glioblastoma and extends beyond T1PC MRI borders. Typical large CTV expansions in pGBM mostly include Cho/NAA > 2x volumes. However, small CTV expansions commonly used in rGBM poorly cover Cho/NAA > 2x, suggesting that larger CTV expansions or Cho/NAA > 2x guidance may be of benefit.
Authors
- Kaylie Cullison (ORCID: https://orcid.org/0000-0001-5341-1530)
- Sulaiman Sheriff
- Jessica Meshman
- Gregory Azzam
- Macarena I. de la Fuente
- Mohammed Goryawala (ORCID: https://orcid.org/0000-0002-6875-2191)
- Matthew C. Abramowitz (ORCID: https://orcid.org/0000-0002-2632-579X)
- Michael E. Ivan (ORCID: https://orcid.org/0000-0002-4798-4989)
- Eric A. Mellon (ORCID: https://orcid.org/0000-0001-9892-8402)
- Jonathan B. Bell (ORCID: https://orcid.org/0000-0002-4978-3566)
Institutions
- University of Miami (US)
- Sylvester Comprehensive Cancer Center (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13014-025-02666-z
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- National Institutes of Health