Ru(II)‐Catalyzed C‐H Alkylation of Indoles at the C‐3 Position with Coumarin‐3‐Carboxylic Acids
Abstract A ruthenium(II)‐catalyzed C3‐selective C─H activation of indoles bearing a pyridyl or pyrimidine directing group and subsequent conjugated/decarboxylative addition to coumarin‐3‐carboxylic acids has been demonstrated. This protocol efficiently afforded a variety of coumarin‐containing indoles with excellent site selectivity, satisfactory product yields, and functional group tolerance.
Authors
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-8076-5094)
- Lina Jia (ORCID: https://orcid.org/0000-0002-0448-4909)
Institutions
- Qiqihar University (CN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/slct.202500281
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Education, Heilongjiang Province
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions