Association between Purpureocillium, amino acid metabolism and cognitive function in drug-naïve, first-episode schizophrenia
Our findings suggest that Purpureocillium might be associated with cognitive impairments through its regulation on the metabolism of specific amino acids involved in inflammation and oxidative stress. A better understanding about the fungal-immune-metabolites association may lead to novel treatment approaches to improve cognitive function in patients with SCZ.
Authors
- Xueqin Song (ORCID: https://orcid.org/0000-0001-9830-7155)
- Yulin Kang (ORCID: https://orcid.org/0000-0002-7875-7930)
- Xiaoduo Fan (ORCID: https://orcid.org/0000-0003-4299-8924)
- Peifen Zhang (ORCID: https://orcid.org/0000-0003-3004-9182)
- Lijuan Pang (ORCID: https://orcid.org/0000-0003-3091-0323)
- Gangrui Hei (ORCID: https://orcid.org/0000-0003-2978-9423)
- Xiuxia Yuan (ORCID: https://orcid.org/0000-0001-8124-3052)
- Xue Li (ORCID: https://orcid.org/0000-0002-4515-6792)
- Xiaoyun Zhang (ORCID: https://orcid.org/0000-0002-6951-9172)
Institutions
- University of Massachusetts Chan Medical School (US)
- Zhengzhou University (CN)
- Chinese Research Academy of Environmental Sciences (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- UMass Memorial Medical Center (US)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12888-025-06965-3
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhengzhou University
- First Affiliated Hospital of Zhengzhou University
- National Key Research and Development Program of China
- Henan Provincial Science and Technology Research Project