Smaller Pancreas Volume in Insulin-Dependent Monogenic Diabetes
Individuals with type 1 diabetes (T1D) have a markedly smaller pancreas, but the mechanism responsible for the reduction in size is unknown. How pancreas volume differs in individuals with specific forms of monogenic diabetes and how pancreas volume relates to the severity of insulin deficiency are unknown. Measured by MRI, individuals with permanent neonatal diabetes due to an INS gene mutation (INS-PND) or the HNF1B gene associated with maturity-onset diabetes of the young had smaller pancreas than individuals without diabetes. Across all types of monogenic diabetes, individuals receiving insulin replacement therapy had smaller pancreas than individuals not using insulin. These results support the conclusion that insulin deficiency is a major factor contributing to changes in pancreas volume in T1D, INS-PND, and other forms of monogenic diabetes.
Authors
- John Virostko (ORCID: https://orcid.org/0000-0003-3413-8801)
- Jonathan M. Williams (ORCID: https://orcid.org/0000-0001-8973-2950)
- Siri Atma W. Greeley (ORCID: https://orcid.org/0000-0002-0741-3567)
- Alvin C. Powers (ORCID: https://orcid.org/0000-0003-1941-5786)
- Daniel J. Moore (ORCID: https://orcid.org/0000-0002-6889-9345)
- Melissa A. Hilmes (ORCID: https://orcid.org/0000-0002-3662-6692)
- Daniel Braun (ORCID: https://orcid.org/0000-0002-6355-3222)
- Lisa R. Letourneau (ORCID: https://orcid.org/0000-0001-9465-4870)
- Louis H. Philipson (ORCID: https://orcid.org/0000-0002-2208-3607)
- J. J. Wright (ORCID: https://orcid.org/0000-0002-2043-0150)
- Balamurugan Kandasamy
Institutions
- Livestrong Foundation (US)
- Vanderbilt University (US)
- University of Chicago (US)
- VA Tennessee Valley Healthcare System (US)
- The University of Texas at Austin (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-05-22
- DOI
- https://doi.org/10.2337/db25-0318
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Vanderbilt University
- Leona M. and Harry B. Helmsley Charitable Trust
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences