Pharmacological Activity of Pinostrobin and Solid Dispersion Based on It

BACKGROUND: The low solubility of pinostrobin in water limits its use, causing technological difficulties and significantly reducing bioavailability. The "solid dispersion method" can significantly increase both the solubility and the release of a number of active substances from various dosage forms. AIM: The purpose of this study is the pharmacological study of pinostrobin and solid dispersion based on it. MATERIAL AND METHODS: Experiments were performed in vitro and in vivo on cells of human hepatocellular carcinoma (HepG2) and on 90 white outbred male and female rats and 24 outbred male mice. Methods were used to assess toxicity and determine antioxidants, hepatoprotective, capillary-strengthening, anti-inflammatory, and anti- ulcer activities. The effects were investigated by cytotoxicity, antioxidant, hepatoprotective, capillary-strengthening, anti-inflammatory, and antiulcer activity of the flavonoid was determined by pinostrobin and its solid dispersion, isolated from the buds of balsam poplar (Populus balsamifera L.). RESULTS: The results of studying biological activity show that this compound is a promising substance for the prevention and complex therapy of various diseases. CONCLUSION: It should be noted that pinostrobin can be considered a potential candidate for the targeted synthesis of a solid dispersion with more pronounced pharmacological effects and relatively high bioavailability.