The Impact of Overexpression of the Mouse Ortholog of CACNA1C on Behavior and Cortical Dynamics
We have successfully generated mice that overexpress the mouse ortholog of a gene that has been implicated in several psychiatric diseases. Our initial characterization suggests that these mice have alterations in behavior and neural function that have been linked to mental illness. It is anticipated that future studies will reveal additional neurobehavioral alterations whose mechanisms will be studied.
Authors
- Lara Ouillette
- Sami L. Case (ORCID: https://orcid.org/0000-0002-1004-7246)
- Emily Glass
- Michael D. Uhler (ORCID: https://orcid.org/0000-0002-2518-8308)
- Geoffrey G. Murphy (ORCID: https://orcid.org/0000-0003-3691-1722)
- Ruei‐Lung Lin (ORCID: https://orcid.org/0000-0001-9041-284X)
- Rachel Parent
- Olivier Thibault (ORCID: https://orcid.org/0000-0002-3548-3466)
- H. Donald Burns (ORCID: https://orcid.org/0000-0002-6425-2173)
Institutions
- University of Kentucky (US)
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100537
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Michigan
- National Institutes of Health