Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA
Earlier detection is a promising strategy to reduce cancer mortality. For cancers of all stages, therapies are more effective with a lower disease burden. In this study, we demonstrate that ctDNA is detectable 3 years or more before cancer diagnosis and provide estimates for the sensitivity required to achieve such very early detection. See related commentary by Crisafulli et al., p. 1774.
Authors
- Lisa Dobbyn (ORCID: https://orcid.org/0000-0002-3159-189X)
- Samuel D. Curtis (ORCID: https://orcid.org/0000-0002-5311-2001)
- Natalie Silliman (ORCID: https://orcid.org/0000-0002-5198-9037)
- Elizabeth A. Platz (ORCID: https://orcid.org/0000-0003-3676-8954)
- Christopher Douville (ORCID: https://orcid.org/0000-0002-2510-4151)
- Janine Ptak (ORCID: https://orcid.org/0000-0003-1934-8739)
- Nickolas Papadopoulos (ORCID: https://orcid.org/0000-0001-7135-7451)
- Meng Ru (ORCID: https://orcid.org/0000-0002-1439-6451)
- Eric Boerwinkle (ORCID: https://orcid.org/0000-0001-8813-0544)
- Maria Popoli (ORCID: https://orcid.org/0000-0003-2151-7749)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Corinne E. Joshu (ORCID: https://orcid.org/0000-0002-5100-172X)
- Kenneth W. Kinzler (ORCID: https://orcid.org/0000-0001-5591-1176)
- Chetan Bettegowda (ORCID: https://orcid.org/0000-0001-9991-7123)
- Bert Vogelstein (ORCID: https://orcid.org/0000-0003-0766-3854)
- Anna E. Prizment (ORCID: https://orcid.org/0000-0001-5924-6871)
- Yuxuan Wang (ORCID: https://orcid.org/0000-0002-2932-6042)
- Vernon A. Burk
Institutions
- University of Minnesota (US)
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Baylor College of Medicine (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Cancer Center (US)
- Cancer Genetics (United States) (US)
- Ludwig Cancer Research (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- New York University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0375
- Citations
- 11
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 10.30