B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with <i>MYC</i> and <i>BCL2</i> Rearrangements

These findings link BCR silencing in IGH isotype-switched t(14;18)+ GC B cells to RAG1/2 expression, which triggers IG light chain editing and predisposes to IGL::MYC translocations, promoting HGBCL. In HGBCL with MYC and BCL2 rearrangements, BCR silencing protects from polatuzumab vedotin killing. See related commentary by Shevchenko and Hodson, p. 284.

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Publication Details

Journal
Blood Cancer Discovery
Published
2025-05-22
DOI
https://doi.org/10.1158/2643-3230.bcd-25-0099
Citations
4
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
5.89
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article

B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements

Stefan Hohaus, Mattia Bugatti, Brunangelo Falini, Henry Yang et al.
4 citations
Blood Cancer Discovery
Lymphoma Diagnosis and Treatment
5.89
article

B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements

Stefan Hohaus, Mattia Bugatti, Brunangelo Falini, Henry Yang, Giorgio Bertolazzi, Daniel Segura-Garzón, Wing C. Chan, Mirko Riboni, Maurilio Ponzoni, Luigi Maria Larocca, Marco Chiarini, Euplio Visco, Sara Torretta, Paola Sindaco, Ciro Mercurio, Arianna Di Napoli, Paolo Trifiró, Elena Maiolo, Joo Y. Song, Reiner Siebert, Filippo Vit, Cecilia Ranise, Raoul J.P. Bonnal, Gaia Morello, Sabrina Giampaolo, Cristina López, Stefano Casola, Emma Albertini, Silvia Lonardi, Hadas Neuman, Rosa Daffini, Silvia Bellesi, Hiroshi Arima, Luisa Lorenzi, Ramit Mehr, Chiara Pagani, Silvia Brambillasca, Federica Mainoldi, Lorenzo Pignataro, Vilma Pellegrini, Gabriele Varano, Elena Morlacchi, Pasquale Capaccio, Simone P. Minardi, Brian Leuzzi, Giada Cicio, Daniele Lorenzini, Michela Robusto, Giancarlo Pruneri, Valeria Cancila, Alessandra Tucci, Adrian Andronache, Marco Ungari, Fabio Facchetti, Marco Pizzi, Piera Balzarini, Andrés J.M. Ferreri, Camillo Almici, Claudio Tripodo, Antonello D. Cabras, Riccardo Bomben, Mario Varasi, Ying Li, Takashi Sonoki, Viveka Selvarasa, Anojan Sivacegaram, Ilaria Pietrini, Nicara C. Parr, Tommaso M. Taddei, Hajdica Thanasi
article en
4 citations

Abstract

These findings link BCR silencing in IGH isotype-switched t(14;18)+ GC B cells to RAG1/2 expression, which triggers IG light chain editing and predisposes to IGL::MYC translocations, promoting HGBCL. In HGBCL with MYC and BCL2 rearrangements, BCR silencing protects from polatuzumab vedotin killing. See related commentary by Shevchenko and Hodson, p. 284.

Blood Cancer DiscoveryVol. 6(4)
Università Cattolica del Sacro Cuore (IT), City Of Hope National Medical Center (US), Optech (Canada) (CA), University of Padua (IT), Bar-Ilan University (IL), Vita-Salute San Raffaele University (IT), Scuola Superiore Sant'Anna (IT), National University of Singapore (SG), University of Milan (IT), Wakayama Medical University (JP), Universität Ulm (DE), Università degli Studi di Enna Kore (IT), University of Perugia (IT), Agostino Gemelli University Polyclinic (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), San Raffaele University of Rome (IT), Azienda Ospedaliera di Perugia (IT), Saint Camillus International University of Health and Medical Sciences (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), National University Cancer Institute, Singapore (SG), City of Hope (US), IFOM (IT), Azienda Ospedaliera Sant'Andrea (IT), Centro di Riferimento Oncologico (IT), IRCCS Ospedale San Raffaele (IT), Fondazione Poliambulanza Istituto Ospedaliero (IT), University of the Sacred Heart (JP), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), European Institute of Oncology (IT), University of Brescia (IT), Sapienza University of Rome (IT), University of Palermo (IT)
Openalex Percentile: Top 4%
Lymphoma Diagnosis and Treatment
5.89
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