B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with <i>MYC</i> and <i>BCL2</i> Rearrangements
These findings link BCR silencing in IGH isotype-switched t(14;18)+ GC B cells to RAG1/2 expression, which triggers IG light chain editing and predisposes to IGL::MYC translocations, promoting HGBCL. In HGBCL with MYC and BCL2 rearrangements, BCR silencing protects from polatuzumab vedotin killing. See related commentary by Shevchenko and Hodson, p. 284.
Authors
- Stefan Hohaus (ORCID: https://orcid.org/0000-0002-5534-7197)
- Mattia Bugatti (ORCID: https://orcid.org/0000-0002-5090-8338)
- Brunangelo Falini (ORCID: https://orcid.org/0000-0002-7198-5965)
- Henry Yang (ORCID: https://orcid.org/0000-0002-1155-8216)
- Giorgio Bertolazzi (ORCID: https://orcid.org/0000-0001-7328-9675)
- Daniel Segura-Garzón (ORCID: https://orcid.org/0000-0003-0210-9571)
- Wing C. Chan (ORCID: https://orcid.org/0000-0002-6243-6008)
- Mirko Riboni (ORCID: https://orcid.org/0009-0000-3167-484X)
- Maurilio Ponzoni (ORCID: https://orcid.org/0000-0002-0055-325X)
- Luigi Maria Larocca (ORCID: https://orcid.org/0000-0003-1739-4758)
- Marco Chiarini (ORCID: https://orcid.org/0000-0003-1000-0461)
- Euplio Visco (ORCID: https://orcid.org/0009-0006-3926-7548)
- Sara Torretta (ORCID: https://orcid.org/0000-0002-8461-6042)
- Paola Sindaco (ORCID: https://orcid.org/0000-0002-3919-2455)
- Ciro Mercurio (ORCID: https://orcid.org/0000-0001-6240-4607)
- Arianna Di Napoli (ORCID: https://orcid.org/0000-0002-3159-5380)
- Paolo Trifiró
- Elena Maiolo (ORCID: https://orcid.org/0000-0001-8956-7502)
- Joo Y. Song (ORCID: https://orcid.org/0000-0003-3497-2513)
- Reiner Siebert (ORCID: https://orcid.org/0000-0001-7433-3703)
- Filippo Vit (ORCID: https://orcid.org/0000-0002-0195-0978)
- Cecilia Ranise (ORCID: https://orcid.org/0009-0008-9481-6292)
- Raoul J.P. Bonnal (ORCID: https://orcid.org/0000-0002-2123-6536)
- Gaia Morello (ORCID: https://orcid.org/0000-0003-3400-8732)
- Sabrina Giampaolo (ORCID: https://orcid.org/0000-0002-3820-5381)
- Cristina López (ORCID: https://orcid.org/0000-0001-6644-1659)
- Stefano Casola (ORCID: https://orcid.org/0000-0001-5580-0986)
- Emma Albertini
- Silvia Lonardi (ORCID: https://orcid.org/0000-0003-0307-4163)
- Hadas Neuman
- Rosa Daffini
- Silvia Bellesi (ORCID: https://orcid.org/0000-0001-7400-1215)
- Hiroshi Arima (ORCID: https://orcid.org/0000-0003-0609-846X)
- Luisa Lorenzi (ORCID: https://orcid.org/0000-0003-2483-2955)
- Ramit Mehr (ORCID: https://orcid.org/0000-0002-4303-6834)
- Chiara Pagani (ORCID: https://orcid.org/0000-0002-6962-4466)
- Silvia Brambillasca (ORCID: https://orcid.org/0009-0005-5900-7930)
- Federica Mainoldi
- Lorenzo Pignataro (ORCID: https://orcid.org/0000-0003-1619-5124)
- Vilma Pellegrini
- Gabriele Varano (ORCID: https://orcid.org/0000-0002-3698-4262)
- Elena Morlacchi
- Pasquale Capaccio (ORCID: https://orcid.org/0000-0002-2876-5721)
- Simone P. Minardi (ORCID: https://orcid.org/0000-0001-7303-3821)
- Brian Leuzzi (ORCID: https://orcid.org/0000-0001-5237-2920)
- Giada Cicio (ORCID: https://orcid.org/0000-0002-4121-5679)
- Daniele Lorenzini (ORCID: https://orcid.org/0000-0002-1425-3354)
- Michela Robusto (ORCID: https://orcid.org/0000-0001-7673-165X)
- Giancarlo Pruneri (ORCID: https://orcid.org/0000-0002-7963-7172)
- Valeria Cancila (ORCID: https://orcid.org/0000-0002-9502-1191)
- Alessandra Tucci (ORCID: https://orcid.org/0000-0003-3052-7463)
- Adrian Andronache (ORCID: https://orcid.org/0009-0002-6961-7829)
- Marco Ungari
- Fabio Facchetti (ORCID: https://orcid.org/0000-0003-4975-2388)
- Marco Pizzi (ORCID: https://orcid.org/0000-0003-4006-7317)
- Piera Balzarini (ORCID: https://orcid.org/0000-0003-2160-0999)
- Andrés J.M. Ferreri (ORCID: https://orcid.org/0000-0001-9606-6124)
- Camillo Almici (ORCID: https://orcid.org/0000-0002-9438-2569)
- Claudio Tripodo (ORCID: https://orcid.org/0000-0002-0821-6231)
- Antonello D. Cabras (ORCID: https://orcid.org/0000-0001-6369-2356)
- Riccardo Bomben (ORCID: https://orcid.org/0000-0002-8746-9404)
- Mario Varasi (ORCID: https://orcid.org/0000-0003-0367-8290)
- Ying Li (ORCID: https://orcid.org/0000-0002-9316-2521)
- Takashi Sonoki (ORCID: https://orcid.org/0000-0002-0211-3311)
- Viveka Selvarasa
- Anojan Sivacegaram
- Ilaria Pietrini
- Nicara C. Parr
- Tommaso M. Taddei
- Hajdica Thanasi
Institutions
- Università Cattolica del Sacro Cuore (IT)
- City Of Hope National Medical Center (US)
- Optech (Canada) (CA)
- University of Padua (IT)
- Bar-Ilan University (IL)
- Vita-Salute San Raffaele University (IT)
- Scuola Superiore Sant'Anna (IT)
- National University of Singapore (SG)
- University of Milan (IT)
- Wakayama Medical University (JP)
- Universität Ulm (DE)
- Università degli Studi di Enna Kore (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- San Raffaele University of Rome (IT)
- Azienda Ospedaliera di Perugia (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- National University Cancer Institute, Singapore (SG)
- City of Hope (US)
- IFOM (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- Centro di Riferimento Oncologico (IT)
- IRCCS Ospedale San Raffaele (IT)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- University of the Sacred Heart (JP)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- European Institute of Oncology (IT)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0099
- Citations
- 4
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.89