Clinical laboratory effectiveness assessment of the use of mouthwash containing titanium nanoparticles by patients with periodontal inflammation

The aim of this study is to evaluate the efficacy of domestic mouthwashes containing titanium glycerosolvate aquacomplex for periodontal inflammations. Materials and methods. The study included 112 patients from volunteer students with the age range of 18 to 24 years. The participants were divided into three groups of 25 persons each. Patients with chronic simple marginal gingivitis were included in groups I and II, while healthy individuals without periodontal deseases were included in the reference group III. The patients of groups I and III used the therapeutic preventive mouthwash Icy Cherry with the proprietary blend of titanium glycerosolvate aquacomplex and sodium hyaluronate. The patients of group II applied a mouthwash commonly used for oral hygiene. The dental exam of patients consisted of DMFT, determination of OHI-S (Green, Vermillion) and PMA. All patients underwent a qulitative examination of mixed saliva to study relative viscosity, pH, oxidation-reduction potential and buffer capacity in the acid direction. The study also used the sialometry test and evaluation of functional activity of minor salivary glands. Results. In group I, the PMA index decreased by 1.99 times after 7 days, 3.85 times after 14 days and 4.91 times after 21 days. In group III, the PMA index decreased by 1.99 times after 7 days, 3.86 times after 14 days and 4.92 times after 21 days (p≤0.05). Conclusion. Effectiveness assessment of the use of the mouthwash Icy Cherry by young patients with chronic simple marginal gingivitis showed improvement in oral hygiene and reduction in inflammation of the gingival margin.