Multiroute administration of Wharton’s jelly mesenchymal stem cells in chronic complete spinal cord injury: A phase I safety and feasibility study
This phase I study, conducted without a control group, suggests that the administration of WJ-MSCs through multiple routes is both safe and potentially effective in patients with chronic complete SCI. However, the observed neurological improvements cannot be solely attributed to WJ-MSC therapy, as concurrent pharmacological and rehabilitative interventions were not controlled. These findings indicated that WJ-MSC therapy may offer a promising approach for enhancing neurological function and quality of life in this challenging patient population. Further research with larger cohorts and extended follow-up is necessary to validate these preliminary results.
Authors
- Erdal Karaöz (ORCID: https://orcid.org/0000-0002-9992-833X)
- Serdar Kabataş (ORCID: https://orcid.org/0000-0003-2691-6861)
- Osman Boyalı (ORCID: https://orcid.org/0000-0002-2500-1718)
- Necati Kaplan (ORCID: https://orcid.org/0000-0001-5672-0566)
- Erek Öztürk (ORCID: https://orcid.org/0000-0002-3799-9650)
- Eyüp Can Savrunlu (ORCID: https://orcid.org/0000-0001-9022-200X)
- Tolga Akkoç
- Ali Genç (ORCID: https://orcid.org/0000-0002-7084-1548)
- Halil Can (ORCID: https://orcid.org/0000-0002-6792-9987)
- Erdinç Civelek
Institutions
- Piri Reis University (TR)
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TR)
- Klinikum Magdeburg (DE)
- Nevşehir Hacı Bektaş Veli University (TR)
- TÜBİTAK Marmara Research Center (TR)
- Istinye University (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- University Hospital Magdeburg (DE)
- Gaziosmanpaşa Taksim Eğitim ve Araştırma Hastanesi (TR)
- Turku City Hospital (FI)
- Liv Hospital (TR)
- Turkish Society of Cardiology (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-05-23
- DOI
- https://doi.org/10.4252/wjsc.v17.i5.101675
- Citations
- 5
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36