Nanomorphology tuning in doxorubicin-loaded liposomes <i>via</i> cooling-induced doxorubicin-crystallization and membrane phase transition
Rational control of doxorubicin (DOX)-loaded liposome morphology was achieved by changing the cooling rate without altering the composition. Slow cooling produced prolate liposomes containing a linear DOX-sulfate fiber-bundle, whereas rapid freezing gave nearly spherical liposomes with a curved DOX-sulfate fiber-bundle. <i>In situ</i> SAXS and <sup>1</sup>H NMR measurements revealed that the morphological differences were determined by the sequence of DOX-sulfate fiber-bundle formation and stiffness increase of the lipid membrane, depending on the cooling rate.
Authors
- Kenjirou Higashi (ORCID: https://orcid.org/0000-0003-2899-4724)
- Ryo Hidaka (ORCID: https://orcid.org/0000-0002-4637-7941)
- Keisuke Ueda (ORCID: https://orcid.org/0000-0003-0235-4323)
- Taisei Tokumoto
- Koki Nishimura (ORCID: https://orcid.org/0000-0003-1654-4558)
- Takeshi Morita (ORCID: https://orcid.org/0000-0002-9721-1298)
- Kunikazu Moribe
- T. Fujimoto
Institutions
- Chiba University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02434j
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science