<i>Escherichia coli</i> Type III Secretion System 2 Is Associated With Patient Mortality in Bloodstream Infections
Genomic islands ETT2 and ETT2-AR are homologous to a T3SS, co-localize within specific E. coli lineages, associate with increased mortality, and increase bacterial virulence through resistance to complement and enhanced host cell adhesion and death.
Authors
- Sanjay Khandelwal (ORCID: https://orcid.org/0000-0002-5661-3856)
- Granger Sutton (ORCID: https://orcid.org/0000-0001-7498-8048)
- Jeffrey S. Bourgeois (ORCID: https://orcid.org/0000-0001-9037-8418)
- Gowthami M. Arepally (ORCID: https://orcid.org/0000-0003-0496-5064)
- Vance G. Fowler (ORCID: https://orcid.org/0000-0002-8048-0897)
- P. Cox (ORCID: https://orcid.org/0000-0002-4636-5668)
- Derrick E. Fouts (ORCID: https://orcid.org/0000-0003-4323-7668)
- Felicia Ruffin (ORCID: https://orcid.org/0000-0003-2176-6462)
- Thomas H. Clarke (ORCID: https://orcid.org/0000-0002-1916-1029)
- Lauren Brinkac (ORCID: https://orcid.org/0000-0002-7549-7280)
- Dennis C. Ko (ORCID: https://orcid.org/0000-0002-0113-5981)
- Joshua T. Thaden (ORCID: https://orcid.org/0000-0002-3250-0697)
- Paa Kwesi Ankrah (ORCID: https://orcid.org/0009-0007-6991-8281)
- Orianna Poteete (ORCID: https://orcid.org/0000-0003-3599-3439)
Institutions
- J. Craig Venter Institute (US)
- Noblis (US)
- Duke University (US)
- Office of Infectious Diseases (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1093/infdis/jiaf265
- Citations
- 1
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 1.80