Enabling an ultra-specific lysosomal polarity fluorescence response <i>via</i> intramolecular π–π stacking-mediated conformational locking
Designing ultra-specific polar fluorescent probes through the strategy of intramolecular π-π interactions was reported. Based on this strategy, a high-performance lysosomal polarity probe, named P-DOTPA, was developed. It exhibits high specificity, ultra-high sensitivity, near-infrared emission, and the ability to generate superoxide radicals (O<sub>2</sub><sup>-</sup>˙) under irradiation.
Authors
- Yanju Luo
- Jiao Lu (ORCID: https://orcid.org/0000-0002-2121-5962)
- Shiyi Tian (ORCID: https://orcid.org/0000-0002-8195-4425)
- Chunbai Xiang (ORCID: https://orcid.org/0000-0002-1880-2816)
- Zhiyun Lu (ORCID: https://orcid.org/0000-0002-1733-4061)
- Binhao Li (ORCID: https://orcid.org/0009-0003-5903-3237)
- Wenxiao Deng
- Yanfei Tan (ORCID: https://orcid.org/0000-0002-5260-7985)
- Chuan Liu (ORCID: https://orcid.org/0000-0002-7711-9785)
- Yan Huang (ORCID: https://orcid.org/0000-0002-4331-0581)
- Jiaqi Su (ORCID: https://orcid.org/0000-0001-6038-0808)
- Y. T. Tan
- Yuxuan Liu (ORCID: https://orcid.org/0009-0005-4960-1610)
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01905b
- Citations
- 1
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China