LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer
Overall, this study advances our knowledge on the mechanisms of EV biogenesis and highlights a novel oncogenic role of LMTK3 in the breast TME, further supporting it as a target for cancer therapy.
Authors
- Katerina Tsilingiri (ORCID: https://orcid.org/0000-0002-9721-9994)
- Mark Samuels (ORCID: https://orcid.org/0000-0002-9299-8343)
- Andrea Lauer Betrán
- Georgios Giamas (ORCID: https://orcid.org/0000-0002-4417-2707)
- Christos Karakostas
- Apostolos Klinakis (ORCID: https://orcid.org/0000-0002-3923-861X)
- Charlotte Turner (ORCID: https://orcid.org/0000-0002-2665-0090)
- William Jones (ORCID: https://orcid.org/0000-0002-1332-6400)
- Simoni Besta
- Reza Shirazi Nia
- Niloufar Poudine
- Richard Goodyear
Institutions
- Zhejiang Chinese Medical University (CN)
- University of Sussex (GB)
- Biomedical Research Foundation of the Academy of Athens (GR)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12943-025-02346-2
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- University of Sussex
- Action Against Cancer