Hyperbranched polymer dots enhance hair follicle regeneration via Wnt/β-catenin activation: A drug-free nanozyme-based approach to hair growth therapy
Our findings demonstrate that HPD serves as a potent activator of hair follicle regeneration, surpassing the efficacy of conventional minoxidil treatment. By modulating Wnt/β-catenin signaling and enhancing follicular proliferation, HPD presents a promising nanomedicine-based approach for non-invasive hair restoration therapies. Future studies should focus on optimizing HPD formulations for clinical translation in treating androgenetic alopecia and related hair disorders.
Authors
- Yen‐Jen Wang (ORCID: https://orcid.org/0000-0002-0425-9154)
- Yu‐Hsuan Lee (ORCID: https://orcid.org/0000-0001-7660-3770)
- Annie Oo Chan
- Jung‐In Yang (ORCID: https://orcid.org/0000-0003-0685-355X)
- Tzong‐Yuan Juang (ORCID: https://orcid.org/0000-0001-6373-9687)
- Siao‐Cian Fan
- Ching Hsuan Lin (ORCID: https://orcid.org/0000-0002-7435-4026)
- Chang‐Cheng Chang (ORCID: https://orcid.org/0000-0002-0463-7346)
- Ching‐Chang Cheng (ORCID: https://orcid.org/0000-0002-6829-6894)
- Yi‐Hsuan Su
- Yuxuan Yang (ORCID: https://orcid.org/0000-0002-1897-997X)
- Wenping Jiang (ORCID: https://orcid.org/0009-0000-5371-3272)
Institutions
- National Chung Hsing University (TW)
- China Medical University (TW)
- Mackay Memorial Hospital (TW)
- China Medical University Hospital (TW)
- Mackay Junior College of Medicine, Nursing and Management (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.biopha.2025.118196
- Citations
- 1
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- China Medical University
- China Medical University, Taiwan