Surgical Resection of Murine PDAC Alters Hepatic Metastases and Immune Microenvironment
Collectively, we describe a preclinical resection model that offers a means to investigate MRD. Using this model, we delineated effects of surgical resection on metastatic outgrowth and uncovered a protective link between the postoperative hepatic eosinophilia and further metastatic progression.
Authors
- Sarah R. Kaslow (ORCID: https://orcid.org/0000-0002-2179-6787)
- Erica Ma (ORCID: https://orcid.org/0000-0002-7708-1094)
- Rafael Winograd (ORCID: https://orcid.org/0000-0003-4304-3724)
- Emma Kurz (ORCID: https://orcid.org/0000-0001-8251-5224)
- Wenqing Cao (ORCID: https://orcid.org/0000-0002-2761-3355)
- Ryte Damaseviciute
- Christopher L. Wolfgang (ORCID: https://orcid.org/0009-0000-5817-6146)
- Dafna Bar‐Sagi (ORCID: https://orcid.org/0000-0003-2597-8948)
- Beny Shapiro (ORCID: https://orcid.org/0000-0002-1067-3458)
- Mansour E. Riachi (ORCID: https://orcid.org/0000-0002-2790-8700)
- Sandra Vogt
- Carolina Alcantara Hirsch (ORCID: https://orcid.org/0000-0003-2193-362X)
- Kwok-Kin Wong
- Juan Andres Kochen Rossi (ORCID: https://orcid.org/0000-0001-6452-0249)
- Ammar A. Javed (ORCID: https://orcid.org/0000-0002-5463-5250)
- Ting Chen (ORCID: https://orcid.org/0000-0001-8414-6346)
- Anthony Sorrentino
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
- Hinge Health (US)
- NYU Langone’s Laura and Isaac Perlmutter Cancer Center
- New York University (US)
Publication Details
- Journal
- Pancreas
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1097/mpa.0000000000002516
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00