Bio-amplified fiber microlaser for ultrasensitive and disposable immunosensing
Based on telecom optical fiber, we report a bio-amplified microlaser for ultrasensitive and disposable immunosensing. A fourorder- of-magnitude-enhancement in sensitivity has been demonstrated for avidin detection. Then, the biolaser is applied for cancer biomarker (PD-L1) detection, achieving a limit of detection of 3.2 pg/mL.
Authors
- Chenxiang Wang (ORCID: https://orcid.org/0000-0002-6879-8640)
- Yuan Gong (ORCID: https://orcid.org/0000-0001-6819-8402)
- Yiling Liu (ORCID: https://orcid.org/0000-0002-9789-1385)
- Chaoyang Gong (ORCID: https://orcid.org/0000-0003-4942-6822)
- Zekai Li (ORCID: https://orcid.org/0009-0002-0143-4057)
- Xi Yang (ORCID: https://orcid.org/0000-0003-1910-497X)
- Yunjiang Rao
Institutions
- University of Electronic Science and Technology of China (CN)
- Chongqing University (CN)
Publication Details
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1117/12.3062143
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00