Development of a low-cost Raman spectroscopy platform for high-throughput analysis

This study describes the development of a low-cost, high-throughput Raman spectroscopy platform for rapid sample analysis. The system consists of 3 main components: a CNC, a USB microscope and a Raman probe, providing a cheaper alternative to commercial systems. The platform combines automated particle coordinates identification with the microscope, followed by a Raman analysis to characterize the sample across a defined area. To validate the proposed system, polypropylene (PP) microplastics were scattered on a glass filter and subjected to the scan. The system scanned an area of 519.84 mm<sup>2</sup> in under 1 hour, detected 481 particles through the microscope and 170 of the spectra acquired with Raman, were identified as PP, demonstrating its capability as an efficient and cost-effective solution. Despite this, the proposed platform is versatile and can be used for different applications, namely when evaluating Raman sensitive coatings through a Raman map, for example on optical fibers.

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Published
2025-05-22
DOI
https://doi.org/10.1117/12.3062778
Primary Topic
Spectroscopy Techniques in Biomedical and Chemical Research
Type
article
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article

Development of a low-cost Raman spectroscopy platform for high-throughput analysis

Guilherme Lopes, A.J.S. Fernandes, Ângela Maria Grossi de Carvalho, Carlos Marques
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Spectroscopy Techniques in Biomedical and Chemical Research
article

Development of a low-cost Raman spectroscopy platform for high-throughput analysis

Guilherme Lopes, A.J.S. Fernandes, Ângela Maria Grossi de Carvalho, Carlos Marques
article en

Abstract

This study describes the development of a low-cost, high-throughput Raman spectroscopy platform for rapid sample analysis. The system consists of 3 main components: a CNC, a USB microscope and a Raman probe, providing a cheaper alternative to commercial systems. The platform combines automated particle coordinates identification with the microscope, followed by a Raman analysis to characterize the sample across a defined area. To validate the proposed system, polypropylene (PP) microplastics were scattered on a glass filter and subjected to the scan. The system scanned an area of 519.84 mm<sup>2</sup> in under 1 hour, detected 481 particles through the microscope and 170 of the spectra acquired with Raman, were identified as PP, demonstrating its capability as an efficient and cost-effective solution. Despite this, the proposed platform is versatile and can be used for different applications, namely when evaluating Raman sensitive coatings through a Raman map, for example on optical fibers.

University of Aveiro (PT)
Industry, innovation and infrastructure
Openalex Percentile: Top 91%
Spectroscopy Techniques in Biomedical and Chemical Research
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Development of a low-cost Raman spectroscopy platform for high-throughput analysis — Guilherme Lopes, A.J.S. Fernandes, et al. · (2025) | TGRS Research Map | TGRS