Pharmaceutical chemical sensing in hollow-core anti-resonant fiber with surfaces functionalized by semiconductor nanoparticles

Hollow-core fibers provide an excellent platform for a variety of research initiatives due to their outstanding characteristics, such as broadband light transmission, enhanced light-matter interactions, ultra-low nonlinearity, low latency and waveguide dispersion. Among these investigations, hollow-core fiber-based chemical sensors have attracted significant interest and show considerable potentials. In this study, we present a novel approach for measuring aqueous tetracycline molecules by modifying the inner surface of a double-nested hollow-core anti-resonant fiber with deposited nanoscale semiconductor CsPbBr₃ particles of perovskite structures. The chemical sensing primarily relies on the fluorescence quenching of CsPbBr₃ nanoparticles upon reacting with aqueous tetracycline. These findings offer a reliable, compatible, and promising solution for chemical and biological sensing of aqueous substances in fiber-based systems.