Logic-gated biolaser for digital biochemical sensing
We report a digital biosensor with the logic gate in an optical fiber microcavity. The logic gate is controlled by analyte-induced DNA conformation changes, switching laser emission through the FRET effect. Logic gates of OR and INHIBIT are demonstrated for digital biosensing with a wide threshold range, about one order of magnitude higher than fluorescence.
Authors
- Tingting Wang (ORCID: https://orcid.org/0000-0001-8051-405X)
- Chenxiang Wang (ORCID: https://orcid.org/0000-0002-6879-8640)
- X. Jessie Yang (ORCID: https://orcid.org/0000-0001-6071-0387)
- Yunjiang Rao (ORCID: https://orcid.org/0000-0003-0717-5586)
- Yuan Gong (ORCID: https://orcid.org/0009-0009-9097-4805)
- Cairong Zhang
- Mateusz Smietana
- Zekai Li
Institutions
- Warsaw University of Technology (PL)
- University of Electronic Science and Technology of China (CN)
Publication Details
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1117/12.3061893
- Primary Topic
- Microfluidic and Capillary Electrophoresis Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00