Integrated fiber-optic drug delivery system for effective anti-tumor synergistic therapy

Effective treatment of malignant tumors remains a thorny issue in current medicine. However, single antitumor therapy suffers from limited treatment efficacy and lack of monitoring of the treatment process. This study presents a synergistic treatment strategy utilizing fiber-optic photothermal therapy (PTT) and chemotherapy, to achieve a synergistic effect in tumor treatment. The fiber-optic system not only delivers drugs directly to the tumor site during PTT, but also provides real-time monitoring of temperature and drug release, ensuring precise and controlled therapy. We tested two chemotherapeutic drugs using the fiber-optic drug release strategy. Both successfully eradicated tumors in cancer xenograft mice models, providing a feasible approach for anti-tumor and anti-recurrence treatment. This fiber-optic synergistic treatment strategy improves the effectiveness anti-tumor therapies, which opens up new avenues for the development of multi-modal and multi-type synergistic fiber-optic therapy.