Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability

We report a 59-year-old man with a progressively deteriorating neurologic presentation characterized by dysarthria and gait instability. Neurologic examination revealed pseudobulbar palsy, cerebellar ataxia, and pyramidal signs. Neuroimaging demonstrated irregular brainstem and cerebellar lesions with minimal mass effect and partial enhancement. Bilateral heel swelling, an uncommon clinical presentation, prompted further diagnostic evaluation. This case highlights the importance of a systematic reasoning approach, emphasizing the differential diagnosis, further investigative modalities, and treatment options for this rare condition, with particular attention to potential multisystem involvement.

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Publication Details

Journal
Neurology
Published
2025-05-22
DOI
https://doi.org/10.1212/wnl.0000000000213729
Primary Topic
Histiocytic Disorders and Treatments
Type
article
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0.00
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article

Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability

Long Chang, Yan You, Xinxin Cao, Dongchao Shen et al.
Neurology
Histiocytic Disorders and Treatments
article

Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability

Long Chang, Yan You, Xinxin Cao, Dongchao Shen, Zhe Zhang, Hongzhi Guan
article en

Abstract

We report a 59-year-old man with a progressively deteriorating neurologic presentation characterized by dysarthria and gait instability. Neurologic examination revealed pseudobulbar palsy, cerebellar ataxia, and pyramidal signs. Neuroimaging demonstrated irregular brainstem and cerebellar lesions with minimal mass effect and partial enhancement. Bilateral heel swelling, an uncommon clinical presentation, prompted further diagnostic evaluation. This case highlights the importance of a systematic reasoning approach, emphasizing the differential diagnosis, further investigative modalities, and treatment options for this rare condition, with particular attention to potential multisystem involvement.

NeurologyVol. 104(12)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN)
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Openalex Percentile: Top 85%
Histiocytic Disorders and Treatments
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Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability — Long Chang, Yan You, et al. · Neurology (2025) | TGRS Research Map | TGRS