Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability
We report a 59-year-old man with a progressively deteriorating neurologic presentation characterized by dysarthria and gait instability. Neurologic examination revealed pseudobulbar palsy, cerebellar ataxia, and pyramidal signs. Neuroimaging demonstrated irregular brainstem and cerebellar lesions with minimal mass effect and partial enhancement. Bilateral heel swelling, an uncommon clinical presentation, prompted further diagnostic evaluation. This case highlights the importance of a systematic reasoning approach, emphasizing the differential diagnosis, further investigative modalities, and treatment options for this rare condition, with particular attention to potential multisystem involvement.
Authors
- Long Chang (ORCID: https://orcid.org/0000-0001-6976-5827)
- Yan You (ORCID: https://orcid.org/0000-0002-2703-5794)
- Xinxin Cao (ORCID: https://orcid.org/0000-0001-7884-3073)
- Dongchao Shen (ORCID: https://orcid.org/0000-0003-0804-4764)
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-5350-0795)
- Hongzhi Guan (ORCID: https://orcid.org/0000-0003-3903-5078)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1212/wnl.0000000000213729
- Primary Topic
- Histiocytic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00